Treatment of familial erythromelalgia with venlafaxine.

Treatment of erythromelalgia with a serotonin/noradrenaline reuptake inhibitor.

(Letter to the Editor) SIR, Erythromelalgia is an unusual disorder characterized by the triad of red, hot and painful extremities. The symptoms are exacerbated by heat and improved by cold. Its aetiology is not fully understood. Numerous different medications including aspirin, gabapentin, amitriptyline, benzodiazepines and opiates have been used in attempts to treat the symptoms of erythromela...

Alleviation of erythromelalgia with venlafaxine.

Treatment of Raynaud's phenomenon with escitalopram.

Serotonin has been shown to play a significant role in diseases related to vascular dysregulation like Raynaud’s phenomenon (Hollenberg, 1988), erythromelalgia (Rudikoff and Jaffe, 1997),migraine (Bonvento et al., 1991) and perimenopausal hot flushes (Berendsen, 2000). In recent years there have been several reports on the efficacy of the selective serotonin reuptake inhibitors (SSRIs) fluoxeti...

Erythromelalgia: a hereditary pain syndrome enters the molecular era.

In contrast with acquired pain syndromes, molecular substrates for hereditary pain disorders have been poorly understood. Familial erythromelalgia (Weir Mitchell's disease), also known as primary erythermalgia, is an autosomal dominant disorder characterized by burning pain in the extremities in response to warm stimuli or moderate exercise. The cause of this disorder has been enigmatic, and tr...

Protective Effects of Simvastatin on Cytotoxicity and Oxidative Stress in Human Gingival Fibroblasts Cells Exposed to Venlafaxine

Background and purpose: Venlafaxine is an antidepressant that belongs to the family of selective serotonin and norepinephrine reuptake inhibitor (SNRIs) drugs. Recent studies have indicated that prolonged use of antidepressants leads to a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection and subsequently induces DNA damage, lipid peroxidatio...